1-(4-氯-2-甲氧基苯基)哌嗪合成路线 (共 1 条)
反应条件
1: With potassium carbonate in diethylene glycol dimethyl ether
T=220°C; 3.5 h; Sealed pressure flask;
2: With sodium hydroxide in dichloromethane; water
pH=9 - 10;
参考文献
ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.
Patent: WO2006/71730 A1, 2006 ;
Location in patent: Page/Page column 80-82 ;
WO 2006/071730 A1