5-溴-2-甲基-1,3-噻唑-4-羧酸合成路线 （共 2 条）
反应条件
hydrogenchloride in diethyl ether 3 h; Heating / reflux;
参考文献
Buettelmann, Bernd; Ceccarelli, Simona Maria; Jaeschke, Georg; Kolczewski, Sabine; Porter, Richard Hugh Philip; Vieira, Eric
Patent: US2006/160857 A1, 2006 ;
Location in patent: Page/Page column 31; 38 ;
US 20060160857 A1
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane
T=-78 - 20°C; 0.25 h;
2: With bromine in tetrahydrofuran; hexane
T=-78 - 20°C;
参考文献
Buettelmann, Bernd; Ceccarelli, Simona Maria; Jaeschke, Georg; Kolczewski, Sabine; Porter, Richard Hugh Philip; Vieira, Eric
Patent: US2006/160857 A1, 2006 ;
Location in patent: Page/Page column 31 ;
US 20060160857 A1
