反应条件
1: potassium carbonate / dimethylformamide
2: acetic acide / Heating
3: 99 percent / piperidine / toluene / 4 h / Heating
4: 92 percent / trimethylbenzyl ammonium hydroxyde / methanol / 24 h
5: 97 percent / hydrogen / Raney nickel / ethanol / 3 h / 80 °C / 45003.6 Torr
6: 1.) sodium; 2.) 6N HCl / 1.) ethanol, water, 31 deg C, 2h; 2.) water, 60 deg C, 1 h
View Scheme
参考文献
Maillard; Langlois; Vo Van; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 353 - 358
