反应条件
1: 96 percent / 2,4,4,6-tetrabromo-2,5-cyclohexadienone / CH2Cl2 / -5 deg C to RT
2: 79 percent / glacial HOAc, drierite / ethanol / 4 h / Heating
3: 70.5 percent / diphenyl ether / 0.42 h / 255 °C
4: 93 percent / POCl3 / 2 h / Heating
5: 86 percent / methanol / 5 h / 120 °C
6: 1) THF, hexane, -70 deg C, 2 min, 2) to -40 deg C
View Scheme
参考文献
Davis, Steven E.; Rauckman, Barbara S.; Chan, Joseph H.; Roth, Barbara
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1936 - 1942
