1: 80 percent / 15 h / 180 - 185 °C
2: 12 g / 1 N NaOH / 1 h / Ambient temperature
3: 87 percent / PPA / 0.67 h / 140 - 150 °C
4: 87.7 percent / 30percent H2O2, conc.HCl / acetic acid / 0.5 h / 85 °C
5: 80.5 percent / methanol / 0.17 h / Heating
6: 56.8 percent / Zn, 1) AcOH, 2) HCl / methanol / Heating; 1) 10 min, 2) 5 min
7: KOH / dimethylformamide / 20 h / 60 - 65 °C
View Scheme
参考文献
Bhide, K. S.; Mujumdar, R. B.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 12 p. 1254 - 1256
1.1: bromine / acetic acid / Inert atmosphere
2.1: sulfuric acid; potassium iodide; sodium nitrite / Inert atmosphere
3.1: dihydrogen peroxide; sodium acetate / acetic acid / 2.5 h / 40 °C / Inert atmosphere
4.1: boron trifluoride diethyl etherate / dichloromethane / 0.25 h / 0 °C / Inert atmosphere
4.2: 1 h / 0 °C / Inert atmosphere
4.3: 0.5 h / Inert atmosphere
5.1: copper acetylacetonate; potassium carbonate / water; toluene / 2.5 h / 20 °C / Inert atmosphere
6.1: boron tribromide
View Scheme
参考文献
Lin, David W.; Masuda, Takeshi; Biskup, Moritz B.; Nelson, Jonathan D.; Baran, Phil S.
Journal of Organic Chemistry, 2011 , vol. 76, # 4 p. 1013 - 1030
1: 2-methoxy-phenylamine With hydrogenchloride; sodium nitrite in water
T=-2 - 0°C; 1 h; Green chemistry;
2: With ascorbic acid powder in water
T=-2 - 0°C; Green chemistry;
3: 3-aminocrotononitrile in water
T=45 - 90°C; Green chemistry;
Duguay,G.; Quiniou,H.
Bulletin de la Societe Chimique de France, 1972 , p. 637 - 645
Full Text Show Details
Brown et al.
Journal of the American Chemical Society, 1957 , vol. 79, p. 2919,2925
