反应条件
1.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 10 h / 120 °C 2.1: boron tribromide / dichloromethane / 0.5 h / -20 - -10 °C 3.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 5 h / 115 - 120 °C 3.2: 20 °C / pH 3 - 4 / Acidic conditions 4.1: sulfuric acid / 1,4-dioxane; water / 5 h / 95 - 100 °C 5.1: acetic acid / methanol / 1 h / 20 °C 5.2: 25 - 45 °C 6.1: sodium hydroxide; water / methanol / 6 h / 20 °C 7.1: sodium hydroxide; dihydrogen peroxide / dimethyl sulfoxide / 6 h / 20 °C View Scheme
参考文献
SANDOZ AG; JOSHI, Shreerang; BHUTA, Sachin; TALUKDAR, Sanjay; SAWANT, Sudhir; VENKATARAMAN, Deepak; PISE, Abhinay; METKAR, Shashikant; CHAVAN, Dattatraya; LUTHRA, Parven, Kumar
Patent: WO2011/30356 A2, 2011 ;