反应条件
1: N-bromosuccinimide, benzoyl peroxide / benzene / 2 h / Heating 2: MeONa, 2-nitropropane / methanol / 7 h / 20 - 40 °C 3: 1.) t-BuOK / 1.) DMSO, RT, 20 min, 2.) DMSO, RT, 2 h 4: AcCl / 2 h / Heating 5: H2 / 5percent Pd/C / methanol / 1 h / Ambient temperature 6: LiAlH4 / diethyl ether / 1 h / Heating 7: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -40 deg C, 25 min, 2.) CH2Cl2, -40 deg C, 5 min View Scheme
参考文献
Hashizume; Ito; Yamada; Nagashima; Kanao; Tomoda; Sunazuka; Kumagai; Omura
Chemical and pharmaceutical bulletin, 1994 , vol. 42, # 3 p. 512 - 520
