2-羟基-4,6-二甲氧基苯乙酮合成路线 （共 113 条）
反应条件
1: 2.1 g / aq. NaOH / ethanol / Ambient temperature; overnight
2: 440 mg / aq. NaOH (2N), H2O2, H2O2 / methanol / 1) 30 min, 2) overnight
3: K2CO3 / acetone
View Scheme
参考文献
Pathak, V. P.; Khanna, R. N.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 9 p. 891 - 892
反应条件
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl acetamide / 12 h / 0 - 20 °C
2: potassium hydroxide; pyridine / 2 h / 60 °C
3: acetic acid; sulfuric acid / 1 h / |Reflux
4: trimethylsilylazide; copper; ethanolamine / N,N-dimethyl acetamide / 4 h / 120 °C / |Sealed tube
View Scheme
参考文献
Shih, Tzenge-Lien; Chou, Chi-En; Liao, Wen-Yu; Hsiao, Chih-Ang
Tetrahedron, 2014 , vol. 70, # 23 p. 3657 - 3664
反应条件
1: 56 percent / POCl2 / pyridine / 3 h / 60 - 70 °C
2: 61 percent / NaH / tetrahydrofuran / 3 h / Heating
3: 65 percent / iodine / 3 h / 80 - 90 °C
View Scheme
参考文献
Barros, Ana I. R. N. A.; Silva, Artur M. S.
Monatshefte fur Chemie, 2006 , vol. 137, # 12 p. 1505 - 1528
反应条件
1: 87 percent / POCl2 / pyridine / 3 h / 60 - 70 °C
2: 63 percent / NaH / tetrahydrofuran / 2.5 h / Heating
3: 54 percent / iodine / 3 h / 80 - 90 °C
View Scheme
参考文献
Barros, Ana I. R. N. A.; Silva, Artur M. S.
Monatshefte fur Chemie, 2006 , vol. 137, # 12 p. 1505 - 1528
反应条件
1: 45 percent / POCl2 / pyridine / 3 h / 60 - 70 °C
2: 47 percent / NaH / tetrahydrofuran / 3.5 h / Heating
3: 63 percent / p-toluenesulfonic acid / dimethylsulfoxide / 80 - 90 °C
View Scheme
参考文献
Barros, Ana I. R. N. A.; Silva, Artur M. S.
Monatshefte fur Chemie, 2006 , vol. 137, # 12 p. 1505 - 1528
反应条件
1: potassium carbonate / acetone / Reflux
2: sodium acetate; acetic acid / Reflux
View Scheme
参考文献
Zheng, Xing; Zhao, Fei Fei; Liu, Yun Mei; Yao, Xu; Zheng, Zi Tong; Luo, Xing; Liao, Duan Fang
Medicinal Chemistry, 2010 , vol. 6, # 1 p. 6 - 8
反应条件
1: concentrated sulfuric acid
2: aluminium chloride; benzene
View Scheme
参考文献
Sastri et al.
Proceedings - Indian Academy of Sciences, Section A, 1953 , # 37 p. 681,690
反应条件
1: 81.4 percent / pyridine / 0.17 h / 100 °C
2: 69.1 percent / KOH / pyridine / 0.17 h / 100 °C
3: 70.8 percent / H2SO4 / acetic acid / 0.17 h / 100 °C
4: 85.4 percent / BBr3 / CH2Cl2 / 5 h / Ambient temperature
5: 73.1 percent / I2, TlOAc / CH2Cl2 / Ambient temperature
6: 71.3 percent / K2CO3 / Heating
7: 50 percent / Pd(PPh3)4, NaOH / dimethylformamide; H2O / 2 h / 80 °C
8: 30 percent / BBr3 / CHCl3 / Heating
View Scheme
参考文献
Zembower, David E.; Zhang, Heping
Journal of Organic Chemistry, 1998 , vol. 63, # 25 p. 9300 - 9305
反应条件
1: (C2H5)3SiH / trifluoroacetic acid / 20 °C
2: BF3*Et2O
View Scheme
参考文献
Mateeva, Nelly N.; Kode, Rao N.; Redda, Kinfe K.
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 6 p. 1251 - 1258
反应条件
1: 81.4 percent / pyridine / 0.17 h / 100 °C
2: 69.1 percent / KOH / pyridine / 0.17 h / 100 °C
3: 70.8 percent / H2SO4 / acetic acid / 0.17 h / 100 °C
View Scheme
参考文献
Srivastava, Savitri D.; Srivastava, Santosh K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, p. 57 - 58
