2-羟基-4,6-二甲氧基苯乙酮合成路线 （共 113 条）
反应条件
1: potassium hydroxide / methanol / 72 h / 20 °C 2: iodine / dimethyl sulfoxide / 4.5 h / 130 °C 3: pyridine hydrochloride / 6.5 h / 180 °C / |Inert atmosphere View Scheme
参考文献
Zhang, Ji; Liu, Man; Cui, Wei; Yang, Jian; Yang, Bo
Journal of Chemical Research, 2014 , vol. 38, # 1 p. 60 - 61
反应条件
1: 81.4 percent / pyridine / 0.17 h / 100 °C 2: 69.1 percent / KOH / pyridine / 0.17 h / 100 °C 3: 70.8 percent / H2SO4 / acetic acid / 0.17 h / 100 °C 4: 85.4 percent / BBr3 / CH2Cl2 / 5 h / Ambient temperature View Scheme
参考文献
Zembower, David E.; Zhang, Heping
Journal of Organic Chemistry, 1998 , vol. 63, # 25 p. 9300 - 9305
反应条件
lt;Fe(DMF)3Cl2gt;lt;FeCl4gt; in methanol; water
参考文献
Parthasarathy,M.R. et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1977 , vol. 15B, p. 942 - 944
反应条件
1: potassium carbonate / acetone / 8 h / 20 °C 2: pyridine; potassium hydroxide / 1 h / 50 °C 3: sulfuric acid; acetic acid / 1 h / 90 °C 4: pyridine hydrochloride / 0.25 h / 220 °C View Scheme
参考文献
Liu, Man; Zhang, Ji; Yang, Jian; Yang, Bo; Cui, Wei
Journal of Chemical Research, 2014 , vol. 38, # 3 p. 134 - 136
反应条件
bromine; acetic acid 0.5 h;
参考文献
Cechinel-Filho; Vaz; Zunino; Calixto; Yunes
European Journal of Medicinal Chemistry, 1996 , vol. 31, # 10 p. 833 - 839
反应条件
1: 94.5 percent / Br2, AcOH / 0.5 h 2: 78 percent / pyridine / 80 - 90 °C View Scheme
参考文献
Cechinel-Filho; Vaz; Zunino; Calixto; Yunes
European Journal of Medicinal Chemistry, 1996 , vol. 31, # 10 p. 833 - 839
参考文献
Beirne,J.J. et al.
Tetrahedron, 1970 , vol. 26, p. 3809 - 3814
反应条件
1: 3.0 g 2: 1.2 g / H3PO4 3: 0.6 g / H2 / Pd-C View Scheme
参考文献
Anand, Preet; Singh, Baldev
Medicinal Chemistry Research, 2013 , vol. 22, # 4 p. 1648 - 1659
反应条件
1: sodium tetrahydroborate / mineral oil; tetrahydrofuran / 48 h / 0 - 20 °C 2: acetic acid; hydrogenchloride / water / 0.5 h / 70 °C View Scheme
参考文献
Hatnapure, Girish D.; Keche, Ashish P.; Rodge, Atish H.; Birajdar, Satish S.; Tale, Rajesh H.; Kamble, Vandana M.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 20 p. 6385 - 6390
反应条件
1: 60 percent / aluminium chloride / chlorobenzene / 1 h / Heating 2: 99 percent / K2CO3 / acetone / Heating 3: 29 percent / NaOH; K2S2O8; pyridine / H2O / 24 h / 20 °C View Scheme
参考文献
Kavvadias, Dominique; Sand, Philipp; Youdim, Kuresh A.; Qaiser, M. Zeeshan; Rice-Evans, Catherine; Baur, Roland; Sigel, Erwin; Rausch, Wolf-Dieter; Riederer, Peter; Schreier, Peter
British Journal of Pharmacology, 2004 , vol. 142, # 5 p. 811 - 820
