2-羟基-4,6-二甲氧基苯乙酮合成路线 （共 113 条）
反应条件
boron tribromide in dichloromethane T=20°C; 3 h;
参考文献
European Journal of Organic Chemistry, , # 6 p. 1107 - 1111
反应条件
sodium hydroxide; water in ethanol several hours;
参考文献
Filho; Miguel; Nunes; Calixto; Yunes
Journal of Pharmaceutical Sciences, 1995 , vol. 84, # 4 p. 473 - 475
反应条件
1: pyridine 2: 13.5 g / KOH / pyridine / 2 h / 40 °C 3: 13.0 g / conc.HCl / acetic acid / 2 h / Heating 4: 10 g / HI (d=1.7) / acetic anhydride / 6 h / 115 - 118 °C View Scheme
参考文献
Wang, Jin; Zhou, Rong-Guang; Wu, Ting; Yang, Tao; Qin, Qi-Xue; Li, Li; Yang, Bo; Yang, Jian
Journal of Chemical Research, 2012 , vol. 36, # 3 p. 121 - 122
反应条件
1.1: bromine; acetic acid / 1 h / 20 °C 2.1: sodium hydroxide / ethanol / 0.08 h 2.2: 20 °C View Scheme
参考文献
Bandgar, Babasaheb P.; Hote, Baliram S.; Dhole, Nagesh A.; Gacche, Rajesh N.
Medicinal Chemistry Research, 2012 , vol. 21, # 9 p. 2292 - 2299
反应条件
1: 60 percent / aluminium chloride / chlorobenzene / 1 h / Heating 2: 99 percent / K2CO3 / acetone / Heating 3: 29 percent / NaOH; K2S2O8; pyridine / H2O / 24 h / 20 °C 4: 59 percent / K2CO3 / acetone / Heating 5: pyridine / 3 h / 20 °C 6: KOH / pyridine / 4 h / 60 °C 7: sulfuric acid / acetic acid / 1.5 h / 60 °C 8: BCl3 / CH2Cl2 / 1.5 h / -65 °C View Scheme
参考文献
British Journal of Pharmacology, , vol. 142, # 5 p. 811 - 820
反应条件
1: o-xylene / 4 h / Reflux; Inert atmosphere 2: sulfuric acid; water / 2 h / Reflux; Inert atmosphere 3: [Rh(OH)(cycloocta-1,5-diene)]2; (S)-MeO-F12-BIPHEP / water; toluene / 3 h / 60 °C / Inert atmosphere View Scheme
参考文献
Korenaga, Toshinobu; Hayashi, Keigo; Akaki, Yusuke; Maenishi, Ryota; Sakai, Takashi
Organic Letters, 2011 , vol. 13, # 8 p. 2022 - 2025
反应条件
sodium hydroxide in chlorobenzene 5 h; Irradiation;
参考文献
Bansal; Singh; Khanna
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996 , vol. 35, # 6 p. 586 - 587
反应条件
1: potassium carbonate / acetone / 8 h / 20 °C 2: pyridine; potassium hydroxide / 1 h / 50 °C View Scheme
参考文献
Hu, Kun; Wang, Wei; Cheng, Hong; Pan, ShaSha; Ren, Jie
Medicinal Chemistry Research, 2011 , vol. 20, # 7 p. 838 - 846
反应条件
AlCl3, aluminium chloride in chlorobenzene 1 h; RefluxSealed tubeSchlenk technique;
参考文献
Wei, Yu; Tang, Jinghua; Cong, Xuefeng; Zeng, Xiaoming
Green Chemistry, 2013 , vol. 15, # 11 p. 3165 - 3169
反应条件
boron tribromide in dichloromethane T=20°C; 3 h;
参考文献
Bringmann, Gerhard; Menche, Dirk; Brun, Reto; Msuta, Thomas; Abegaz, Berhanu
European Journal of Organic Chemistry, 2002 , # 6 p. 1107 - 1111
