2-羟基-4,6-二甲氧基苯乙酮合成路线 （共 113 条）
反应条件
3,3-dimethyldioxirane in dichloromethane; acetone
T=0 - 20°C; 0.166667 h;
参考文献
Chu, Han-Wei; Wu, Huan-Ting; Lee, Yean-Jang
Tetrahedron, 2004 , vol. 60, # 11 p. 2647 - 2655
反应条件
1: With potassium hydroxide in methanol
T=20°C; 80 h;
2: With hydrogenchloride in methanol; water
pH=5 - 6;
参考文献
Liu, Man; Zhang, Ji; Yang, Jian; Yang, Bo; Cui, Wei
Journal of Chemical Research, 2014 , vol. 38, # 3 p. 134 - 136
反应条件
1: 0.52 g / KOH / ethanol; H2O / Ambient temperature
2: pyridine / Ambient temperature
3: 1., Tl(NO3)2*3H2O; 2.) KOH; 3.) 10percent HCl / 1.) MeOH, RT; 2.) 1 h; 3.) reflux, 1.5 h
4: 65 mg / H2 / 10percent Pd/C / acetic acid / Ambient temperature
View Scheme
参考文献
Ingham, John L.; Dewick, Paul M.
Phytochemistry (Elsevier), 1980 , vol. 19, p. 2799 - 2800
反应条件
1: pyridine
2: 13.5 g / KOH / pyridine / 2 h / 40 °C
3: 13.0 g / conc.HCl / acetic acid / 2 h / Heating
4: 10 g / HI (d=1.7) / acetic anhydride / 6 h / 115 - 118 °C
5: 250 mg / BF3*Et2O / 45 - 50 °C
View Scheme
参考文献
Roy, D; Khanna, R. N.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 7 p. 583 - 586
反应条件
chlorine in tetrachloromethane
18 h;
参考文献
Acton, John P.; Donnelly, Dorothy J.; Donnelly, John A.
Monatshefte fuer Chemie, 1982 , vol. 113, p. 73 - 80
反应条件
chlorine in tetrachloromethane
18 h;
参考文献
Acton, John P.; Donnelly, Dorothy J.; Donnelly, John A.
Monatshefte fuer Chemie, 1982 , vol. 113, p. 73 - 80
反应条件
1: 1.) NaNO2, 20 percent HCl 2.) 10 percent NaOH / 1.) water, 0 - 4 deg C, 0.5 h, 2.) ethanol, water, 4 - 8 deg C, 72 h
View Scheme
参考文献
Acton, John P.; Donnelly, Dorothy J.; Donnelly, John A.
Monatshefte fuer Chemie, 1982 , vol. 113, p. 73 - 80
反应条件
in pyridine
T=100°C; 0.166667 h;
参考文献
Zembower, David E.; Zhang, Heping
Journal of Organic Chemistry, 1998 , vol. 63, # 25 p. 9300 - 9305
反应条件
1: 62 percent / POCl2 / pyridine / 3 h / 60 - 70 °C
2: 58 percent / NaH / tetrahydrofuran / 3 h / Heating
3: 52 percent / iodine / 3 h / 80 - 90 °C
View Scheme
参考文献
Zheng, Xing; Zhao, Fei Fei; Liu, Yun Mei; Yao, Xu; Zheng, Zi Tong; Luo, Xing; Liao, Duan Fang
Medicinal Chemistry, 2010 , vol. 6, # 1 p. 6 - 8
反应条件
1.1: sodium peroxodisulphate; sodium hydroxide / water
2.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 3 h / -78 - -10 °C / |Inert atmosphere
2.2: -78 - 20 °C / |Inert atmosphere
2.3: |Cooling with ice
3.1: acetic acid; sulfuric acid / 3.5 h / 95 °C
4.1: lithium hydroxide hydrate / tetrahydrofuran; methanol / 2 h / 20 °C
View Scheme
参考文献
Twincore Zentrum für Experimentelle und Klinische Infektionsforschung GmbH; CNRS Centre National de la Recherche Scientifique; Université de Strasbourg; Pietschmann, Thomas; Haid, Sibylle; Gentzsch, Juliane; Grethe, Christina; Davioud-Charvet, Elisabeth; Lanfranchi, Don Antoine; Elhabiri, Mourad; Benlloch-Martin, Xavier
Patent: EP2641904 A1, 2013 ;
