Pseudoephedrine合成路线 （共 47 条）
反应条件
1: 13.0 g / Et3N / CH2Cl2 / 1 h / 0 °C 2: 84 percent / HCl / methanol / 3 h / 0 °C / other solvent, reagent View Scheme
参考文献
Myers, Andrew G.; Gleason, James L.; Yoon, Taeyoung
Journal of the American Chemical Society, 1995 , vol. 117, # 32 p. 8488 - 8489
反应条件
Yield given. Multistep reaction;
参考文献
Myers, Andrew G.; Gleason, James L.; Yoon, Taeyoung
Journal of the American Chemical Society, 1995 , vol. 117, # 32 p. 8488 - 8489
反应条件
hydrogenchloride; pivaloyl chloride; triethylamine 1) CH2Cl2, 0 deg C, 30 min, 2) CH2Cl2, 0 deg C, 45 min, 3) MeOH, H2O, 0 deg C, 3 h; Multistep reaction;
参考文献
Myers, Andrew G.; Yoon, Taeyoung; Gleason, James L.
Tetrahedron Letters, 1995 , vol. 36, # 26 p. 4555 - 4558
反应条件
n-butyllithium; lithium chloride 1) THF, 0 deg C, 10 min, 2) THF, hexane, 0 deg C, 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Myers, Andrew G.; Yoon, Taeyoung; Gleason, James L.
Tetrahedron Letters, 1995 , vol. 36, # 26 p. 4555 - 4558
参考文献
Blagg, Julian; Davies, Stephen G.
Tetrahedron, 1987 , vol. 43, # 19 p. 4463 - 4472
反应条件
1: 98 percent / K2CO3 / benzene / Heating 2: HCO2H / 16 h / Heating View Scheme
参考文献
Page, Philip C. Bulman; Heaney, Harry; Reignier, Serge; Rassias, Gerasimos A.
Synlett, 2003 , # 1 p. 22 - 28
参考文献
Smith
Journal of the Chemical Society, 1927 , p. 2058
反应条件
1: (+/-)-B-allenyl-10-trimethylsilyl-9-borabicyclo[3.3.2]decane; benzaldehyde in diethyl ether
T=-78°C;
2: (-)-lt;R-(R*,S*)gt;-Ephedrin in acetonitrile
4 h; Heating;
参考文献
Lai, Chunqiu; Soderquist, John A.
Organic Letters, 2005 , vol. 7, # 5 p. 799 - 802
反应条件
1: (+/-)-B-allenyl-10-trimethylsilyl-9-borabicyclo[3.3.2]decane; butyraldehyde in diethyl ether
T=-78°C; 3 h;
2: (-)-lt;R-(R*,S*)gt;-Ephedrin in acetonitrile
4 h; Heating;
参考文献
Lai, Chunqiu; Soderquist, John A.
Organic Letters, 2005 , vol. 7, # 5 p. 799 - 802
反应条件
hydrogenchloride; ammonium chloride; ammonia in tetrahydrofuran; diethyl ether
参考文献
King, Clifford Riley; Bristol, David W.; English, Michael L.
Patent: US2014/178480 A1, 2014 ;
Location in patent: Page/Page column ;
