反应条件
1.1: 98 percent / triflic acid; Et3SiH / CH2Cl2 / 12 h / 25 °C
2.1: Bu3N; Ph3P / Pd(OAc)2 / 0.08 h / 25 °C
2.2: Bu3N / 3 h / 110 °C
2.3: 67 percent / Pd(OAc)2 / 24 h / 110 °C
3.1: 70 percent / H2 / Pd/C / ethyl acetate / 10 h / 25 °C
4.1: 91 percent / aq. NaOH / tetrahydrofuran; methanol / 3 h / 25 °C
View Scheme
参考文献
Hardouin, Christophe; Kelso, Michael J.; Romero, F. Anthony; Rayl, Thomas J.; Leung, Donmienne; Hwang, Inkyu; Cravatt, Benjamin F.; Boger, Dale L.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 14 p. 3359 - 3368
