2-[5-(氯甲基)-1,2,4-恶二唑-3-基]吡啶合成路线 （共 5 条）
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane; toluene T=0 - 20°C; Reflux;
参考文献
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.; LAWRENCE, Harshani R.; SEBTI, Said M.; OZCAN, Sevil
Patent: WO2012/129564 A2, 2012 ;
Location in patent: Page/Page column 143 ;
WO 2012/129564 A2
反应条件
in toluene 2 h; RefluxMolecular sieve;
参考文献
Ozcan, Sevil; Kazi, Aslamuzzaman; Marsilio, Frank; Fang, Bin; Guida, Wayne C.; Koomen, John; Lawrence, Harshani R.; Sebti, Said M.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 10 p. 3783 - 3805
反应条件
in toluene 2 h; RefluxMolecular sieve;
参考文献
Sindkhedkar, Milind Dattatraya; Desai, Vijaya Narayan; Loriya, Rajesh Maganlal; Patel, Mahesh Vithalbhai; Trivedi, Bharat Kalidas; Bora, Rajesh Onkardas; Diwakar, Santosh Devidas; Jadhav, Ganesh Rajaram; Pawar, Shivaji Sampatrao
Patent: US2009/247478 A1, 2009 ;
Location in patent: Page/Page column 46-47 ;
反应条件
2: toluene / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 3 p. 457 - 465
反应条件
1: hydroxylamine hydrochloride; sodium carbonate / water / 14 h / 70 °C 2: acetone / 0.5 h / 20 °C 3: toluene / 2 h / |Reflux; |Molecular sieve View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 10 p. 3783 - 3805
