(6ci,7ci,9ci)-1H-吲唑-3-羧酰胺合成路线 （共 4 条）
反应条件
trifluoroacetic anhydride in pyridine; dichloromethane T=20°C; 0.166667 h;
参考文献
MERCK and CO., INC.
Patent: WO2008/54605 A2, 2008 ;
Location in patent: Page/Page column 64 ;
WO 2008/054605 A2
反应条件
1: With 4-methyl-morpholine; isobutyl chloroformate in tetrahydrofuran
T=-20°C; 2 h; Inert atmosphere;
2: With ammonia in tetrahydrofuran; water
T=20°C; 1 h;
参考文献
Patel, Maulik R.; Pandya, Kashyap G.; Lau-Cam, Cesar A.; Singh, Satyakam; Pino, Maria A.; Billack, Blase; Degenhardt, Kurt; Talele, Tanaji T.
Chemical Biology and Drug Design, 2012 , vol. 79, # 4 p. 488 - 496
反应条件
ammonia in methanol
T=110°C; 96 h;
参考文献
MERCK and CO., INC.
Patent: WO2008/54605 A2, 2008 ;
Location in patent: Page/Page column 63 ;
WO 2008/054605 A2
反应条件
ammonium hydroxide in tetrahydrofuran
T=0 - 20°C; 5 h;
参考文献
Shi, Jing-Jing; Ji, Fei-Hong; He, Pei-Lan; Yang, Ya-Xi; Tang, Wei; Zuo, Jian-Ping; Li, Yuan-Chao
ChemMedChem, 2013 , vol. 8, # 5 p. 722 - 725
