1: With n-butyllithium in tetrahydrofuran
T=-78°C; 0.333333 h;
2: With boric acid trimethyl ester in tetrahydrofuran
T=-78 - 20°C; 21 h;
3: With hydrogenchloride; water in tetrahydrofuran
参考文献
Bristol-Myers Squibb Company
Patent: US2007/3539 A1, 2007 ;
Location in patent: Page/Page column 89 ;
US 20070003539 A1
