4’-(三氟甲基)联苯-4-甲醛合成路线 （共 14 条）
反应条件
1: in propan-1-ol T=70°C; 0.25 h; 2: With water; sodium carbonate; palladium diacetate; triphenylphosphine in propan-1-ol 1 h; Reflux;
参考文献
Pfizer Inc.
Patent: US2012/165343 A1, 2012 ;
Location in patent: Page/Page column 15 ;
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in 1,1-dimethoxyethane; water Suzuki Coupling; 18 h; Heating / reflux;
参考文献
BAYER HEALTHCARE AG
Patent: WO2006/63811 A2, 2006 ;
Location in patent: Page/Page column 30 ;
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in toluene Inert atmosphereReflux;
参考文献
PROZYMEX A/S; PEDERSEN, John; LAURITZEN, Conni
Patent: WO2012/130299 A1, 2012 ;
Location in patent: Page/Page column 113 ;
WO 2012/130299 A1
反应条件
potassium carbonate; thiourearesin-bound Pd in water; isopropyl alcohol Arylation; Suzuki cross-coupling; 4 h; Heating;
参考文献
Zhang, Tony Y.; Allen, Matthew J.
Tetrahedron Letters, 1999 , vol. 40, # 32 p. 5813 - 5816
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in 1,1-dimethoxyethane; water 18 h; Heating / reflux;
参考文献
Bayer HealthCare AG
Patent: EP1216225 B1, 2005 ;
Location in patent: Page/Page column 43 ;
反应条件
NiCl2(PCy3)2 in benzene T=25°C; 1 h;
参考文献
Hirner, Joshua J.; Blum, Suzanne A.
Organometallics, 2011 , vol. 30, # 6 p. 1299 - 1302
反应条件
palladium diacetate in pet; hexane; dichloromethane
反应条件
in tetrahydrofuran; hexane; water
反应条件
1: 4-trifluoromethyl-1-iodobenzene With copper; zinc in N,N-dimethyl-formamide T=100°C; 0.166667 h; 2: 4-bromo-benzaldehyde With bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide T=120°C; Negishi cross-coupling reaction; 0.0833333 h; Further stages.;
参考文献
Tetrahedron Letters, , vol. 45, # 20 p. 3909 - 3912
反应条件
NiCl2(PCy3)2 in benzene T=25°C; 2 h;
参考文献
Organometallics, , vol. 30, # 6 p. 1299 - 1302
