氢氯吡格雷合成路线

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ZENTIVA A.S.
Patent: WO2006/42481 A1, 2006 ;
Location in patent: Page/Page column 11 ;

28783-41-74,5,6,7-四氢噻吩并[3,2-c]吡啶盐酸盐+

85259-19-4alpha-溴-2-氯苯乙酸甲酯

90055-48-4氢氯吡格雷

参考文献

IPCA Laboratories Limited
Patent: EP1772455 A2, 2007 ;
Location in patent: Page/Page column 9 ;

929200-21-5+

77-78-1硫酸二甲酯

90055-48-4氢氯吡格雷

参考文献

Zhejiang Huahai Pharmaceutical Co., Ltd.; CHENGDU ORGANIC CHEMICALS CO., LTD., CHINESE ACADE
Patent: EP1942110 A1, 2008 ;
Location in patent: Page/Page column 20 ;

113665-84-2氯吡格雷+

120202-69-9氯吡格雷杂质C

90055-48-4氢氯吡格雷

参考文献

RICHTER GEDEON NYRT.
Patent: WO2009/77797 A1, 2009 ;
Location in patent: Page/Page column 11 ;

54903-50-34,5,6,7-四氢噻吩并[3.2-c]吡啶+

57486-68-72-氯苯乙酸甲酯

90055-48-4氢氯吡格雷

参考文献

Evans, Ryan W.; Zbieg, Jason R.; Zhu, Shaolin; Li, Wei; Macmillan, David W. C.
Journal of the American Chemical Society, 2013 , vol. 135, # 43 p. 16074 - 16077

90055-48-4氢氯吡格雷

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Kansal, Vinod Kumar; Praveen, Kompally; Mistry, Dhirenkumar N.
Patent: US2008/287679 A1, 2008 ;
Location in patent: Page/Page column 6-7 ;

944046-20-2+

28783-41-74,5,6,7-四氢噻吩并[3,2-c]吡啶盐酸盐

90055-48-4氢氯吡格雷

参考文献

ZENTIVA A.S.
Patent: WO2006/42481 A1, 2006 ;
Location in patent: Page/Page column 5-6 ;

1130832-68-6

90055-48-4氢氯吡格雷

参考文献

Kalinski, Cedric; Lemoine, Hugues; Schmidt, Juergen; Burdack, Christoph; Kolb, Juergen; Umkehrer, Michael; Ross, Guenther
Synthesis, 2008 , # 24 art. no. T05808SS, p. 4007 - 4011

67-56-1甲醇+

90055-55-3

90055-48-4氢氯吡格雷

参考文献

Kalinski, Cedric; Lemoine, Hugues; Schmidt, Juergen; Burdack, Christoph; Kolb, Juergen; Umkehrer, Michael; Ross, Guenther
Synthesis, 2008 , # 24 art. no. T05808SS, p. 4007 - 4011

85259-19-4alpha-溴-2-氯苯乙酸甲酯

90055-48-4氢氯吡格雷

参考文献

IPCA Laboratories Limited
Patent: EP1772455 A2, 2007 ;
Location in patent: Page/Page column 10 ;