1-氯-4-碘-2,5-二甲氧基苯合成路线 （共 10 条）
反应条件
n-butyllithium 1.) ether, hexane, 10 min, 2.) ether, hexane, a) RT, 10 min, b) reflux, 10 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Sargent, Thornton; Shulgin, Alexander T.; Mathis, Chester A.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1071 - 1077
参考文献
Posternak et al.
Helvetica Chimica Acta, 1948 , vol. 31, p. 525,535
反应条件
iodine cloride in acetonitrile
T=70°C; 4 h;
参考文献
Wariishi, Koji; Morishima, Sin-Ichi; Inagaki, Yoshio
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 98 - 100
反应条件
iodine cloride in dichloromethane
1.) RT, 1 h, 2.) reflux, 20 min;
参考文献
Sargent, Thornton; Shulgin, Alexander T.; Mathis, Chester A.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1071 - 1077
反应条件
iodine; mercury(II) oxide
ultrasound, 10 min, 90 deg C, 30 min;
参考文献
Huenig, Siegfried; Bau, Robert; Kemmer, Martina; Meixner, Hubert; Metzenthin, Tobias; et al.
European Journal of Organic Chemistry, 1998 , # 2 p. 335 - 348
反应条件
sulfuric acid; potassium iodide
T=75°C; Diazotization;
参考文献
Posternak et al.
Helvetica Chimica Acta, 1948 , vol. 31, p. 525,535
反应条件
1: tin (II)-chloride
2: aqueous H2SO4; KI / 75 °C / Diazotization
View Scheme
参考文献
Posternak et al.
Helvetica Chimica Acta, 1948 , vol. 31, p. 525,535
反应条件
2: acetic acid; aqueous nitric acid / unter Kuehlung
3: tin (II)-chloride
4: aqueous H2SO4; KI / 75 °C / Diazotization
View Scheme
参考文献
Posternak et al.
Helvetica Chimica Acta, 1948 , vol. 31, p. 525,535
反应条件
chloroform; chlorine
Behandeln des Produkts mit Natronlauge und Reduzieren der gebildeten Jodosoverbindungen mit angesaeuerter Kaliumjodidloesung oder Kochen mit Wasser;
参考文献
Kauffmann; Fritz
Chemische Berichte, 1908 , vol. 41, p. 4424
反应条件
n-butyllithium
1.) ether, hexane, 10 min, 2.) ether, hexane, a) RT, 10 min, b) reflux, 10 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Sargent, Thornton; Shulgin, Alexander T.; Mathis, Chester A.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1071 - 1077
