4-碘-2,5-二甲氧基苯甲醛合成路线 （共 5 条）
反应条件
iodine; silver nitrate in methanol
7 h;
参考文献
Hathaway, Bruce A.; Taylor, Brian E.; Wittenborn, Jeremy S.
Synthetic Communications, 1998 , vol. 28, # 24 p. 4629 - 4637
反应条件
1: I2DMB With n-butyllithium in diethyl ether; hexane
T=-10 - -5°C; 1.33333 h;
2: N,N-dimethyl-formamide in diethyl ether; hexane
T=20°C; 6 h;
参考文献
Ko, Soo-Byung; Cho, An-Na; Kim, Mi-Jeong; Lee, Chang-Ryul; Park, Nam-Gyu
Dyes and Pigments, 2012 , vol. 94, # 1 p. 88 - 98
反应条件
1.1: iodine; periodic acid / methanol / 4 h / 70 °C
2.1: n-butyllithium / diethyl ether; hexane / 1.33 h / -10 - -5 °C
2.2: 6 h / 20 °C
View Scheme
参考文献
Ko, Soo-Byung; Cho, An-Na; Kim, Mi-Jeong; Lee, Chang-Ryul; Park, Nam-Gyu
Dyes and Pigments, 2012 , vol. 94, # 1 p. 88 - 98
反应条件
n-butyllithium
1.) ether, hexane, 10 min, 2.) ether, hexane, a) RT, 10 min, b) reflux, 10 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Sargent, Thornton; Shulgin, Alexander T.; Mathis, Chester A.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1071 - 1077
反应条件
1: 40 percent / ammonium acetate / 6 h / Heating
2: 52 percent / electrolytic Fe, AcOH / 0.5 h / Heating
View Scheme
参考文献
Sargent, Thornton; Shulgin, Alexander T.; Mathis, Chester A.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1071 - 1077
