2-氨基-7-甲基-3H-吡咯并[2,3-d]嘧啶-4(7H)-酮合成路线 （共 5 条）
反应条件
potassium carbonate in methanol
1 h; Heating / reflux;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2005/99688 A2, 2005 ;
Location in patent: Page/Page column 315 ;
WO 2005/099688 A2
反应条件
4-MeC6H4SNa in N,N,N',N',N'',N''-hexamethylphosphoric triamide; toluene
4 h; Heating;
参考文献
Seela; Bussmann; Gotze; Rosemeyer
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 981 - 985
反应条件
sodium hydroxide in methanol
3 h; Heating;
参考文献
Seela; Bussmann; Gotze; Rosemeyer
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 981 - 985
反应条件
sodium hydroxide
6 h; Heating;
参考文献
Hoops, Geoffrey C.; Park, Julie; Garcia, George A.; Townsend, Leroy B.
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 3 p. 767 - 781
反应条件
1: 1.) NaH / 1.) DMF, 2.) DMF, 25 deg C, 24 h
2: 76 percent / aq. NaOH / 6 h / Heating
View Scheme
参考文献
Hoops, Geoffrey C.; Park, Julie; Garcia, George A.; Townsend, Leroy B.
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 3 p. 767 - 781
