2-氨基-3,7-二氢-3-甲基-4H-吡咯并[2,3-d]嘧啶-4-酮合成路线 （共 8 条）
反应条件
sodium hydroxide
1.5 h; Ambient temperature;
参考文献
Seela; Bussmann; Gotze; Rosemeyer
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 981 - 985
反应条件
1: 80 percent / NaOH / 2 h / 120 °C
2: BCl3 / CH2Cl2 / 17 h / -20 °C
3: conc. aq. ammonia / methanol / 17 h / Ambient temperature
View Scheme
参考文献
Seela; Bussmann; Gotze; Rosemeyer
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 981 - 985
反应条件
1: BCl3 / CH2Cl2 / 17 h / -20 °C
2: conc. aq. ammonia / methanol / 17 h / Ambient temperature
View Scheme
参考文献
Seela; Bussmann; Gotze; Rosemeyer
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 981 - 985
反应条件
1: 60 percent / 50percent aq. NaOH, benzyltriethylammonium chloride / CH2Cl2; 1,2-dimethoxy-ethane / 1 h
2: 80 percent / NaOH / 2 h / 120 °C
3: BCl3 / CH2Cl2 / 17 h / -20 °C
4: conc. aq. ammonia / methanol / 17 h / Ambient temperature
View Scheme
参考文献
Seela; Bussmann; Gotze; Rosemeyer
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 981 - 985
反应条件
ammonia; sodium; sodium hydride
1.) DMF, 0.5 h, 25 deg C, 2.) DMF, -78 deg C, 0.5 h; Yield given. Multistep reaction;
参考文献
Hoops, Geoffrey C.; Park, Julie; Garcia, George A.; Townsend, Leroy B.
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 3 p. 767 - 781
反应条件
1: 1.) NaH / 1.) DMF, 25 deg C, 2.) DMF, 25 deg C, 24 h
2: 62 percent / aq. NaOH / 6 h / Heating
3: 1.) NaH / 1.) DMF, 2.) DMF, 25 deg C, 24h
4: 1.) NaH, 2.) liq. NH3, Na / 1.) DMF, 0.5 h, 25 deg C, 2.) DMF, -78 deg C, 0.5 h
View Scheme
参考文献
Hoops, Geoffrey C.; Park, Julie; Garcia, George A.; Townsend, Leroy B.
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 3 p. 767 - 781
反应条件
1: 62 percent / aq. NaOH / 6 h / Heating
2: 1.) NaH / 1.) DMF, 2.) DMF, 25 deg C, 24h
3: 1.) NaH, 2.) liq. NH3, Na / 1.) DMF, 0.5 h, 25 deg C, 2.) DMF, -78 deg C, 0.5 h
View Scheme
参考文献
Hoops, Geoffrey C.; Park, Julie; Garcia, George A.; Townsend, Leroy B.
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 3 p. 767 - 781
反应条件
1: 1.) NaH / 1.) DMF, 2.) DMF, 25 deg C, 24h
2: 1.) NaH, 2.) liq. NH3, Na / 1.) DMF, 0.5 h, 25 deg C, 2.) DMF, -78 deg C, 0.5 h
View Scheme
参考文献
Hoops, Geoffrey C.; Park, Julie; Garcia, George A.; Townsend, Leroy B.
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 3 p. 767 - 781
