3,7-二氢-7-(甲氧基甲基)-3-甲基-2-(甲硫基)-4H-吡咯并[2,3-d]嘧啶-4-酮合成路线 (共 3 条)
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in ethylene glycol dimethyl ether; dichloromethane
1 h;
参考文献
Seela; Bussmann; Gotze; Rosemeyer
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 981 - 985
反应条件
1: 80 percent / NaOH / 2 h / 120 °C
2: BCl3 / CH2Cl2 / 17 h / -20 °C
3: conc. aq. ammonia / methanol / 17 h / Ambient temperature
View Scheme
参考文献
Seela; Bussmann; Gotze; Rosemeyer
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 981 - 985
反应条件
sodium hydroxide
T=120°C; 2 h;
参考文献
Seela; Bussmann; Gotze; Rosemeyer
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 981 - 985