1: 2-amino-3-[6-bromo-2(1H)-quinolon-4-yl]propionic acid; 2-amino-3-lt;2-(1H)-quinolinon-4-ylgt;propionic acid hydrochloride With sodium hydroxide; hydrogen; Raney nikel in water T=20°C; 2 h; 2: 4-chloro-benzoyl chloride With sodium hydroxide in water; acetone T=0°C; 3: With hydrogenchloride in water; acetone

hydrogenchloride; sodium hydroxide; sodium ethanolate in water

1: With sodium hydroxide in water; acetone T=0°C; 2: With hydrogenchloride in water; acetone

potassium carbonate in water; acetone 2 h;

1: 69 percent / sodium / ethanol / 2 h 2: 89 percent / 20 percent hydrochloric acid / 9 h / Heating 3: 49 percent / K2CO3 / acetone; H2O / 2 h View Scheme

1: 89 percent / 20 percent hydrochloric acid / 9 h / Heating 2: 49 percent / K2CO3 / acetone; H2O / 2 h View Scheme