hydrogen; palladium on activated charcoal in methanol T=20°C; 12 h;

1: With samarium diiodide in tetrahydrofuran; methanol T=-78 - 20°C; 2 h; Inert atmosphere; 2: With acetic acid in tetrahydrofuran; methanol T=20°C; Inert atmosphere;

1: 90 percent / F2; MeCN; H2O / CH2Cl2 / 0 °C 2: 85 percent / aq. tetrabutylammonium hydroxide / CH2Cl2 / 72 h / 20 °C 3: 98 percent / H2 / Pd/C / methanol / 12 h / 20 °C View Scheme

1: 85 percent / aq. tetrabutylammonium hydroxide / CH2Cl2 / 72 h / 20 °C 2: 98 percent / H2 / Pd/C / methanol / 12 h / 20 °C View Scheme