3-溴-4-乙氧基-5-甲氧基苯甲醛合成路线 （共 4 条）
反应条件
1: 3-methoxy-4-hydroxy-5-bromo-benzaldehyde With potassium carbonate in N,N-dimethyl-formamide T=80°C; 0.0833333 h; 2: ethyl iodide in N,N-dimethyl-formamide T=80°C;
参考文献
Nakhjiri, Maryam; Safavi, Maliheh; Alipour, Eskandar; Emami, Saeed; Atash, Amir Farzin; Jafari-Zavareh, Mona; Ardestani, Sussan K.; Khoshneviszadeh, Mehdi; Foroumadi, Alireza; Shafiee, Abbas
European Journal of Medicinal Chemistry, 2012 , vol. 50, p. 113 - 123
反应条件
potassium carbonate in N,N-dimethyl-formamide T=100°C; 2 h;
参考文献
EXONHIT S.A.; LEBLOND, Bertrand; TAVERNE, Thierry; BEAUSOLEIL, Eric; CHAUVIGNAC, Cedric; CASAGRANDE, Anne-Sophie; DESIRE, Laurent
Patent: WO2011/151423 A1, 2011 ;
Location in patent: Page/Page column 191 ;
反应条件
1.1: bromine; acetic acid / 1 h / 20 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 80 °C 2.2: 80 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 50, p. 113 - 123
反应条件
1: 90 percent / Heating
2: 1.) BuLi / 1.) ether, hexane, -80 deg C, 15 min, 2.) ether, hexane, from -80 deg C to RT
3: aq. HCl / 2 h / 100 °C
4: 46 percent / ammonium acetate / 1 h / Heating
5: AlH3 / tetrahydrofuran / 0.5 h / Heating
View Scheme
参考文献
Jacob, Peyton; Shulgin, Alexander T.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 7 p. 881 - 888
