barium dihydroxide in ethanol; water Ambient temperature;

1: 68 percent / DCC; Et3N / CH2Cl2 / 16 h / 20 °C 2: 75 percent / aq. NaOH / methanol / 16 h / 20 °C 3: 89 percent / DCC; EtN / CH2Cl2 / 16 h / 20 °C 4: 70 percent / aq. NaOH / methanol / 16 h / 20 °C View Scheme

1: Et3N / dimethylformamide / 0.5 h 2: 89 percent / Ba(OH)2.8H2O / ethanol; H2O / Ambient temperature View Scheme

1: 89 percent / DCC; EtN / CH2Cl2 / 16 h / 20 °C 2: 70 percent / aq. NaOH / methanol / 16 h / 20 °C View Scheme

1: 75 percent / aq. NaOH / methanol / 16 h / 20 °C 2: 89 percent / DCC; EtN / CH2Cl2 / 16 h / 20 °C 3: 70 percent / aq. NaOH / methanol / 16 h / 20 °C View Scheme