4-(4-甲酰苯氧基)苄腈合成路线 （共 13 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=150 - 160°C; 3 h;
参考文献
Li, Bing; Pai, Ramdas; Cardinale, Steven C.; Butler, Michelle M.; Peet, Norton P.; Moir, Donald T.; Bavari, Sina; Bowlin, Terry L.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 5 p. 2264 - 2276
反应条件
potassium carbonate in N,N-dimethyl-formamide T=100°C; Inert atmosphere;
参考文献
MERCK SERONO S.A.; THUNUGUNTLA, Siva Sanjeeva Rao; SUBRAMANYA, Hosahalli; KUNNAM, Satish Reddy; SANIVARU VIJAY, Sekhar Reddy; BINGI, Chakrapani; KUSANUR, Raviraj; SCHWARZ, Matthias; ARLT, Michael
Patent: WO2010/115736 A2, 2010 ;
Location in patent: Page/Page column 126-127 ;
WO 2010/115736 A2
反应条件
potassium carbonate in N,N-dimethyl-formamide T=155 - 160°C; 3 h;
参考文献
Dann; Ruff; Wolff; Griessmeier
1984 , vol. 1984, # 3 p. 409 - 425
反应条件
Cu2(1,4-benzenedicarboxylic acid)2(1,4-diazabicyclo[2.2.2]octane); potassium carbonate in N,N-dimethyl-formamide T=100°C; 2 h; Inert atmosphere;
参考文献
ChemCatChem, , vol. 5, # 8 p. 2374 - 2381
反应条件
1: 12 percent / piperidine / 24 h / 100 °C
2: 77 percent / triethylphosphite / 20 h / Heating
View Scheme
参考文献
Dann; Ruff; Wolff; Griessmeier
1984 , vol. 1984, # 3 p. 409 - 425
反应条件
1: With sodium tetrahydroborate in methanol
T=20°C; 0.5 h;
2: With water in methanol
参考文献
SMITHKLINE BEECHAM CORPORATION; BOUILLOT, Anne Marie Jeanne; DODIC, Nerina; GELLIBERT, Francoise Jeanne; MIRGUET, Olivier
Patent: WO2010/15652 A2, 2010 ;
Location in patent: Page/Page column 48 ;
WO 2010/015652 A2
反应条件
1: 89 percent / sodium tetrahydroborate / H2O; methanol / 0.5 h
2: 85 percent / pyridine, thionylchloride / diethyl ether / 3 h / Ambient temperature
View Scheme
参考文献
Dann; Ruff; Wolff; Griessmeier
1984 , vol. 1984, # 3 p. 409 - 425
反应条件
1: 89 percent / sodium tetrahydroborate / H2O; methanol / 0.5 h
2: 85 percent / pyridine, thionylchloride / diethyl ether / 3 h / Ambient temperature
3: 82 percent
View Scheme
参考文献
Dann; Ruff; Wolff; Griessmeier
1984 , vol. 1984, # 3 p. 409 - 425
反应条件
1: 92 percent / piperidine / 24 h / 100 °C
2: 78 percent / triethylphosphite / 20 h / Heating
3: 2) 2N HCl / 2) 1 h
View Scheme
参考文献
Dann; Ruff; Wolff; Griessmeier
1984 , vol. 1984, # 3 p. 409 - 425
反应条件
1: 89 percent / sodium tetrahydroborate / H2O; methanol / 0.5 h
2: 85 percent / pyridine, thionylchloride / diethyl ether / 3 h / Ambient temperature
3: 62 percent
View Scheme
参考文献
Dann; Ruff; Wolff; Griessmeier
1984 , vol. 1984, # 3 p. 409 - 425
