1: 4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-yl-amide methanesulphonic salt With methanesulfonic acid in water T=95 - 105°C; 1.33333 - 1.66667 h; 2: methanesulfonyl chloride With sodium hydrogencarbonate in water; ethyl acetate T=15 - 25°C; 2.5 - 3.75 h;

1: 4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-yl-amide methanesulphonic salt With methanesulfonic acid in water T=15 - 105°C; 1.33333 - 1.66667 h; Industry scale; 2: With sodium hydrogencarbonate in water T=15 - 25°C; 3: methanesulfonyl chloride in water T=15 - 25°C; 2.5 - 3.75 h; Product distribution / selectivity;

triethylamine in 1,4-dioxane T=45°C; 2 h;

benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in N,N-dimethyl-formamide T=20°C; 20 h; Product distribution / selectivity;

1: in water T=15 - 105°C; 1.33333 - 1.66667 h; 2: With sodium hydrogencarbonate in water; ethyl acetate T=15 - 25°C; 2.5 - 3.75 h; Product distribution / selectivity;