1: 2-thiopheneacetonitrile With potassium hexamethylsilazane in tetrahydrofuran; toluene T=0°C; 0.05 h; 2: methyl iodide in tetrahydrofuran; toluene 0.25 h;

1: diethyl ether; sodium amide / anschliessend mit Methyljodid behandeln 2: sodium amide; diethyl ether View Scheme

lithium amide; diethyl ether