4-(1-甲基-4-哌啶基甲氧基)苯胺合成路线 （共 4 条）
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in methanol
T=20°C; P=2999.46 Torr; 1 h;
参考文献
SYNTARGA B.V.; GEORG-AUGUST-UNIVERSITAet GOeTTINGEN STIFTUNG OeFFENTLICHEN RECHTS (OHNE BEREICH HUMANMEDIZIN)
Patent: WO2007/89149 A2, 2007 ;
Location in patent: Page/Page column 97 ;
反应条件
1: 83 percent / NaH / dimethylsulfoxide / 3 h / 70 °C
2: 82 percent / H2; HCl / Pd/C / methanol / 1 h / 20 °C / 2999.46 Torr
View Scheme
参考文献
Tietze, Lutz F.; Major, Felix
European Journal of Organic Chemistry, 2006 , # 10 p. 2314 - 2321
反应条件
1: 100 percent / H2 / Pd/C / acetic acid; H2O / 3.5 h / 20 °C / 2999.46 Torr
2: 84 percent / LiAlH4 / diethyl ether / 4 h / 20 °C
3: 83 percent / NaH / dimethylsulfoxide / 3 h / 70 °C
4: 82 percent / H2; HCl / Pd/C / methanol / 1 h / 20 °C / 2999.46 Torr
View Scheme
参考文献
Tietze, Lutz F.; Major, Felix
European Journal of Organic Chemistry, 2006 , # 10 p. 2314 - 2321
反应条件
1: 84 percent / LiAlH4 / diethyl ether / 4 h / 20 °C
2: 83 percent / NaH / dimethylsulfoxide / 3 h / 70 °C
3: 82 percent / H2; HCl / Pd/C / methanol / 1 h / 20 °C / 2999.46 Torr
View Scheme
参考文献
Tietze, Lutz F.; Major, Felix
European Journal of Organic Chemistry, 2006 , # 10 p. 2314 - 2321
