potassium hydroxide in methanol 1 h;

1: 79 percent / TiCl4 / CH2Cl2 / 1 h / 0 °C 2: 74 percent / BBr3 / CH2Cl2 / 1 h / 0 °C 3: 79.6 percent / K2CO3 / butan-2-one / 4.5 h / Heating 4: 82.9 percent / H2, conc.H2SO4 / 20percent Pd/C / acetic acid / 2 h / 2280 Torr 5: LiCl, Me2SO, H2O / 2 h / Heating 6: H2SO4 / Ambient temperature 7: 69.2 percent / AlCl3 / 1,2-dichloro-ethane / 3.75 h / 5 - 20 °C 8: 20 percent / NH2OH*HCl, pyridine / 4 h / Heating 9: 58 percent / 1 h / 90 °C 10: NaH / dimethylformamide / 4 h / Ambient temperature 11: 92 percent / aq. KOH / methanol / 1 h View Scheme

1: 74 percent / BBr3 / CH2Cl2 / 1 h / 0 °C 2: 79.6 percent / K2CO3 / butan-2-one / 4.5 h / Heating 3: 82.9 percent / H2, conc.H2SO4 / 20percent Pd/C / acetic acid / 2 h / 2280 Torr 4: LiCl, Me2SO, H2O / 2 h / Heating 5: H2SO4 / Ambient temperature 6: 69.2 percent / AlCl3 / 1,2-dichloro-ethane / 3.75 h / 5 - 20 °C 7: 20 percent / NH2OH*HCl, pyridine / 4 h / Heating 8: 58 percent / 1 h / 90 °C 9: NaH / dimethylformamide / 4 h / Ambient temperature 10: 92 percent / aq. KOH / methanol / 1 h View Scheme

1: 79.6 percent / K2CO3 / butan-2-one / 4.5 h / Heating 2: 82.9 percent / H2, conc.H2SO4 / 20percent Pd/C / acetic acid / 2 h / 2280 Torr 3: LiCl, Me2SO, H2O / 2 h / Heating 4: H2SO4 / Ambient temperature 5: 69.2 percent / AlCl3 / 1,2-dichloro-ethane / 3.75 h / 5 - 20 °C 6: 20 percent / NH2OH*HCl, pyridine / 4 h / Heating 7: 58 percent / 1 h / 90 °C 8: NaH / dimethylformamide / 4 h / Ambient temperature 9: 92 percent / aq. KOH / methanol / 1 h View Scheme

1: 82.9 percent / H2, conc.H2SO4 / 20percent Pd/C / acetic acid / 2 h / 2280 Torr 2: LiCl, Me2SO, H2O / 2 h / Heating 3: H2SO4 / Ambient temperature 4: 69.2 percent / AlCl3 / 1,2-dichloro-ethane / 3.75 h / 5 - 20 °C 5: 20 percent / NH2OH*HCl, pyridine / 4 h / Heating 6: 58 percent / 1 h / 90 °C 7: NaH / dimethylformamide / 4 h / Ambient temperature 8: 92 percent / aq. KOH / methanol / 1 h View Scheme

1: 69.2 percent / AlCl3 / 1,2-dichloro-ethane / 3.75 h / 5 - 20 °C 2: 20 percent / NH2OH*HCl, pyridine / 4 h / Heating 3: 58 percent / 1 h / 90 °C 4: NaH / dimethylformamide / 4 h / Ambient temperature 5: 92 percent / aq. KOH / methanol / 1 h View Scheme

1: LiCl, Me2SO, H2O / 2 h / Heating 2: H2SO4 / Ambient temperature 3: 69.2 percent / AlCl3 / 1,2-dichloro-ethane / 3.75 h / 5 - 20 °C 4: 20 percent / NH2OH*HCl, pyridine / 4 h / Heating 5: 58 percent / 1 h / 90 °C 6: NaH / dimethylformamide / 4 h / Ambient temperature 7: 92 percent / aq. KOH / methanol / 1 h View Scheme

1: 20 percent / NH2OH*HCl, pyridine / 4 h / Heating 2: 58 percent / 1 h / 90 °C 3: NaH / dimethylformamide / 4 h / Ambient temperature 4: 92 percent / aq. KOH / methanol / 1 h View Scheme

1: 58 percent / 1 h / 90 °C 2: NaH / dimethylformamide / 4 h / Ambient temperature 3: 92 percent / aq. KOH / methanol / 1 h View Scheme

1: NaH / dimethylformamide / 4 h / Ambient temperature 2: 92 percent / aq. KOH / methanol / 1 h View Scheme