2-(甲基硫代)吡啶并[4,3-d]嘧啶-5(6h)-酮合成路线 （共 3 条）
反应条件
ammonium acetate in N,N-dimethyl-formamide
96 h; Reflux;
参考文献
MERCK PATENT GMBH; SCHIEMANN, Kai; SCHULTZ, Melanie; STAEHLE, Wolfgang; KOBER, Ingo; WIENKE, Dirk; KRIER, Mireille
Patent: WO2010/63352 A1, 2010 ;
Location in patent: Page/Page column 89 ;
WO 2010/063352 A1
反应条件
1: ethyl acetate / 12 h / 110 °C / |Sealed tube
2: ammonium chloride / methanol / 48 h / 120 °C / |Sealed tube
View Scheme
参考文献
AbbVie Inc.; Woods, Keith W.; Mastracchio, Anthony; Lai, Chunqiu; Gandhi, Viraj B.; Penning, Thomas D.
Patent: US2013/225589 A1, 2013 ;
反应条件
1: triethylamine / ethanol / 2 h / |Reflux
2: ammonium acetate / ethanol / 1.83 h / 78 °C
3: potassium carbonate; N-iodo-succinimide / acetonitrile / 3 h / 75 °C
View Scheme
参考文献
MERCK PATENT GMBH; BURGDORF, Lars; KUHN, Daniel; ROSS, Tatjana; DEUTSCH, Carl
Patent: WO2014/23385 A1, 2014 ;
