(R)-2-羟基-4-苯基丁酸乙酯合成路线 （共 57 条）
反应条件
hydrogenchloride in ethanol
参考文献
Tetrahedron Letters, , vol. 29, # 4 p. 423-426
反应条件
1: With (DHQD)2AQN in diethyl ether T=-78°C; 24 h; 2: With water Further stages. Title compound not separated from byproducts.;
参考文献
Journal of the American Chemical Society, , vol. 124, # 12 p. 2870 - 2871
反应条件
1: 100 percent / p-toluenesulfonic acid*H2O / benzene / 5 h / Heating 2: 29 percent / H2 / 5percent Pd/C / propan-2-ol / 5 h / 50 °C / 2280 Torr 3: 86 percent / KOH / ethanol / 16 h / Ambient temperature 4: 98 percent / conc. H2SO4 / 16 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 11 p. 1984 - 1991
反应条件
1: 29 percent / H2 / 5percent Pd/C / propan-2-ol / 5 h / 50 °C / 2280 Torr 2: 86 percent / KOH / ethanol / 16 h / Ambient temperature 3: 98 percent / conc. H2SO4 / 16 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 11 p. 1984 - 1991
反应条件
[Ru(II)(η6-benzene)(μ-Cl)Cl]2; C58H42O2P2; hydrogen in methanol; N,N-dimethyl-formamide T=20°C; P=3800.26 Torr; 20 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Chemistry - A European Journal, , vol. 15, # 30 p. 7302 - 7305
反应条件
1: H2; iso-cinchonine / 5 percent Pt/Al2O3 / toluene / 1.5 h / 25 °C / 45003.6 Torr 2: 98 percent / HCl; H2 / 5 percent Pd/C / 40 °C / 825.07 Torr View Scheme
参考文献
Synthesis, , # 11 p. 1679 - 1682
反应条件
water; Pseudomonas lipase enzyme Ambient temperature0.05 M aq. phoshate buffer (pH 7.0); Yields of byproduct given;
参考文献
Journal of Organic Chemistry, , vol. 55, # 3 p. 812 - 815
反应条件
sulfuric acid 5 h; Inert atmosphereReflux;
参考文献
Tetrahedron, , vol. 67, # 34 p. 6186 - 6190
反应条件
1: 80 percent / Saccharomyces cerevisiae cells; phenacyl chloride / H2O; various solvent(s); diisopropyl ether / 48 h / 20 °C / pH 4.5 2: 98 percent / HCl; H2 / Pd/C / ethanol / 6 h View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 15, # 21 p. 3443 - 3447
反应条件
1: 92 percent / sodium ethoxide / benzene / 8 - 10 °C 2: 80 percent / Saccharomyces cerevisiae cells; phenacyl chloride / H2O; various solvent(s); diisopropyl ether / 48 h / 20 °C / pH 4.5 3: 98 percent / HCl; H2 / Pd/C / ethanol / 6 h View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 15, # 21 p. 3443 - 3447
