(R)-2-羟基-4-苯基丁酸乙酯合成路线 （共 57 条）
反应条件
1: 94 percent / H2; AcOH / Pd/C / 20 °C / 760 Torr 2: 95 percent / H2SO4 / 2 h / Heating 3: 100 percent / pyridine / CH2Cl2 / 20 °C 4: ethanol / 48 h / Heating 5: 3.6 g / K2CO3 / ethanol / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 12, # 11 p. 1583 - 1587
反应条件
1: 72 percent / AlCl3 / 4 h / Heating 2: 94 percent / H2; AcOH / Pd/C / 20 °C / 760 Torr 3: 95 percent / H2SO4 / 2 h / Heating 4: 100 percent / pyridine / CH2Cl2 / 20 °C 5: ethanol / 48 h / Heating 6: 3.6 g / K2CO3 / ethanol / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 12, # 11 p. 1583 - 1587
反应条件
1: LiAlH4 / tetrahydrofuran 2: 75 percent / alkaline 3: hydrogen / 10percent Pd/C / acetic acid 4: 67 percent View Scheme
参考文献
Tetrahedron Letters, , vol. 38, # 9 p. 1593 - 1596
反应条件
1: hydrogen / 10percent Pd/C / acetic acid 2: 67 percent View Scheme
参考文献
Tetrahedron Letters, , vol. 38, # 9 p. 1593 - 1596
反应条件
1: 75 percent / alkaline 2: hydrogen / 10percent Pd/C / acetic acid 3: 67 percent View Scheme
参考文献
Tetrahedron Letters, , vol. 38, # 9 p. 1593 - 1596
反应条件
vinyl acetate in various solvent(s) T=25°C; 30 h; lipase PS;
参考文献
Tetrahedron Asymmetry, , vol. 6, # 3 p. 651 - 652
反应条件
1: (E)-2-oxo-4-phenylbut-3-enoic acid With hydrogenchloride; [RuCl(benzene){(2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine)}]Cl; water; hydrogen in tetrahydrofuran T=90°C; P=20686.5 Torr; 10 h; Autoclave; 2: ethanol With sulfuric acid 5 h; Inert atmosphereReflux; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Organic Chemistry, , vol. 75, # 17 p. 6027 - 6030
反应条件
1: 70 percent / calcium alginate; citrate-phosphate buffer; aq. ammonia / glucose; Saccharomyces cerevisiae / ethanol / 24 h / 30 °C / pH 4.0 2: 95 percent / sodium acetate; hydrogen / palladium on carbon / ethanol / 2 h / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 16, # 18 p. 3099 - 3106
反应条件
1: 86 percent / KOH / ethanol / 16 h / Ambient temperature 2: 98 percent / conc. H2SO4 / 16 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 11 p. 1984 - 1991
反应条件
1: H2O / 24 h / 30 °C / bakers' yeast 2: 76.5 percent / n-Bu3SnH, AIBN / benzene View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 2 p. 486 - 492
