(R)-2-羟基-4-苯基丁酸乙酯合成路线 （共 57 条）
反应条件
1: 89 percent / NaNO2, 2N H2SO4, 4N H2SO4 / aq. acetic acid / 24 h, r.t.; 3 h, 100 deg C 2: 65 percent / SOCl2 / 24 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 37, # 2 p. 280 - 283
反应条件
1: (+/-)-2-hydroxy-4-phenylbut-3-enoic acid With hydrogenchloride; [RuCl(benzene){(2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine)}]Cl; water; hydrogen in tetrahydrofuran P=20686.5 Torr; 5 h; Autoclave; 2: ethanol With sulfuric acid 5 h; Inert atmosphereReflux; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Organic Chemistry, , vol. 75, # 17 p. 6027 - 6030
反应条件
in various solvent(s) T=25°C; 30 h; lipase PS;
参考文献
Tetrahedron Asymmetry, , vol. 6, # 3 p. 651 - 652
参考文献
Tetrahedron Letters, , vol. 38, # 9 p. 1593 - 1596
反应条件
1: pyridinium p-toluenesulfonate 2: 1N NaOH 3: conc-sulfuric acid View Scheme
参考文献
Tetrahedron Letters, , vol. 30, # 15 p. 1917 - 1920
反应条件
1: 1N NaOH 2: conc-sulfuric acid View Scheme
参考文献
Tetrahedron Letters, , vol. 30, # 15 p. 1917 - 1920
反应条件
dimethylsulfide; ozone 1) -65 deg C, 2) r.t., 1h; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 31, # 25 p. 3567 - 3570
反应条件
sulfuric acid Yield given;
参考文献
Tetrahedron Letters, , vol. 30, # 15 p. 1917 - 1920
反应条件
sodium phosphate buffer; octadecyl-Sepabeads-Bacillus thermocatenulatus lipase BTL2 in water T=25°C; pH=7.5; Product distribution; Further Variations:ReagentsTemperaturesSolvents;
参考文献
Tetrahedron Asymmetry, , vol. 14, # 23 p. 3679 - 3687
反应条件
1: pyridine / CH2Cl2 / Ambient temperature 2: N(C2H5)3 / CH2Cl2 / Ambient temperature 3: H2 / Pd/C / ethanol / 760 Torr / Ambient temperature View Scheme
参考文献
Urbach, H.; Henning, R.
Tetrahedron Letters, 1984 , vol. 25, # 11 p. 1143 - 1146
