(R)-2-羟基-4-苯基丁酸乙酯合成路线 （共 57 条）
反应条件
pyridine in dichloromethane T=0°C; 0.5 h;
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 11 p. 1984 - 1991
反应条件
sodium hydroxide in water T=20 - 70°C;
参考文献
Glueck, Silvia M.; Larissegger-Schnell, Barbara; Csar, Katrin; Kroutil, Wolfgang; Faber, Kurt
Chemical Communications, 2005 , # 14 p. 1904 - 1905
反应条件
1: 85 percent / CH2Cl2; pyridine / 2 h / 10 °C 2: 10percent aq. Na2CO3 / CH2Cl2 / 5 h / Ambient temperature 3: 91 percent / HCl / CH2Cl2 / 16 h / Ambient temperature View Scheme
参考文献
Attwood, Michael R.; Hassall, Cedric H.; Kroehn, Antonin; Lawton, Geoffrey; Redshaw, Sally
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 1011 - 1020
反应条件
1: 100 percent / pyridine / CH2Cl2 / 0.5 h / 0 °C 2: 80 percent / Et3N / CH2Cl2 / 16 h / Ambient temperature 3: 94 percent / NaH / dimethylformamide / 5 h / Ambient temperature 4: 78 percent / 4 N aq. HCl / dioxane / 16 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 11 p. 1984 - 1991
反应条件
1: 100 percent / pyridine / CH2Cl2 / 0.5 h / 0 °C 2: 80 percent / Et3N / CH2Cl2 / 16 h / Ambient temperature View Scheme
参考文献
Yanagisawa, Hiroaki; Ishihara, Sadao; Ando, Akiko; Kanazaki, Takuro; Miyamoto, Shuichi; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 1984 - 1991
反应条件
1: 100 percent / pyridine / CH2Cl2 / 0.5 h / 0 °C 2: 80 percent / Et3N / CH2Cl2 / 16 h / Ambient temperature 3: 94 percent / NaH / dimethylformamide / 5 h / Ambient temperature 4: 78 percent / 4 N aq. HCl / dioxane / 16 h / Ambient temperature 5: 96 percent / 1 N aq. NaOH / 16 h / Ambient temperature View Scheme
参考文献
Yanagisawa, Hiroaki; Ishihara, Sadao; Ando, Akiko; Kanazaki, Takuro; Miyamoto, Shuichi; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 1984 - 1991
反应条件
1: 74 percent / Et3N / toluene / 1 h / Ambient temperature
2: 84 percent / N-methylmorpholin, HCl / 9 h / 80 °C
View Scheme
参考文献
Boyer; Pfund r.; Portmann; Sedelmeier; Wetter
Helvetica Chimica Acta, 1988 , vol. 71, # 2 p. 337 - 343
