1-(2-四氢吡喃基)-1H-吡唑-5-硼酸频哪酯合成路线 （共 6 条）
反应条件
1: 1-(tetrahydro-pyran-2-yl)-1H-pyrazole With n-butyllithium in tetrahydrofuran T=-70°C; 2: With tri-isopropoxy-borane in tetrahydrofuran T=-70°C; 3: 2,3-dimethylbutane-2,3-diol With acetic acid in tetrahydrofuran T=-70°C;
参考文献
Gerard, Anne-Laure; Mahatsekake, Clement; Collot, Valerie; Rault, Sylvain
Tetrahedron Letters, 2007 , vol. 48, # 23 p. 4123 - 4126
反应条件
1: 1-(tetrahydro-pyran-2-yl)-1H-pyrazole With n-butyllithium in tetrahydrofuran; hexane T=-78 - -70°C; 2: tri-isopropoxy-borane in tetrahydrofuran; hexane T=-70 - 20°C; 3: 2,3-dimethylbutane-2,3-diol in tetrahydrofuran; hexane 0.166667 h;
参考文献
NERVIANO MEDICAL SCIENCES S.R.L.; PULICI, Maurizio; ZUCCOTTO, Fabio; BADARI, Alessandra; NUVOLONI, Stefano; CERVI, Giovanni; TRAQUANDI, Gabriella; BIONDARO, Sonia; TRIFIRO', Paolo; MARCHIONNI, Chiara; MODUGNO, Michele
Patent: WO2010/10154 A1, 2010 ;
Location in patent: Page/Page column 147-148 ;
WO 2010/010154 A1
反应条件
acetic acid in tetrahydrofuran T=20°C; 4 h;
参考文献
McLaughlin, Mark; Marcantonio, Karen; Chen, G-Yi; Davies, Ian W.
Journal of Organic Chemistry, 2008 , vol. 73, # 11 p. 4309 - 4312
反应条件
1.1: 100 percent / TFA / Heating 2.1: n-BuLi / tetrahydrofuran / -70 °C 2.2: triisopropylborate / tetrahydrofuran / -70 °C 2.3: 90 percent / AcOH / tetrahydrofuran / -70 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 47, # 27 p. 4665 - 4669
反应条件
caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in ethylene glycol dimethyl ether; water T=100°C; 0.5 h; Microwave irradiationInert atmosphere;
参考文献
NERVIANO MEDICAL SCIENCES S.R.L.; PULICI, Maurizio; MARCHIONNI, Chiara; TRAQUANDI, Gabriella; SCOLARO, Alessandra; DONATI, Daniele
Patent: WO2012/16993 A1, 2012 ;
Location in patent: Page/Page column 138-139 ;
WO 2012/016993 A1
反应条件
caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in 1,4-dioxane; water T=100°C; 4 h; Inert atmosphere;
参考文献
NERVIANO MEDICAL SCIENCES S.R.L.; PULICI, Maurizio; MARCHIONNI, Chiara; TRAQUANDI, Gabriella; SCOLARO, Alessandra; DONATI, Daniele
Patent: WO2012/16993 A1, 2012 ;
Location in patent: Page/Page column 55-56 ;
WO 2012/016993 A1
