1: 1-fluoro-4-(methylsulfonyl)benzene With n-butyllithium in tetrahydrofuran T=-78°C; 0.333333 h; 2: N-(4-cyano-3-trifluoromethyl-phenyl)-2-oxo-propionamide in tetrahydrofuran T=-78 - 20°C; Further stages.;
参考文献
Parent, Ephraim E.; Dence, Carmen S.; Jenks, Carl; Sharp, Terry L.; Welch, Michael J.; Katzenellenbogen, John A.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 5 p. 1028 - 1040
1: 4-cyano-3-(trifluoromethyl)phenylisocyanide With titanium tetrachloride in dichloromethane Passerini reaction; 1 h; Cooling with ice; 2: 1-(4-fluorophenylsulfonyl)propan-2-one in dichloromethane Passerini reaction; 3 h; 3: With water in dichloromethane 0.333333 h;
