N-[4-氰基-3-(三氟甲基)苯基]甲基环氧丙烯酰胺合成路线 （共 18 条）
反应条件
tungsten(VI) trioxide hydrate in acetic anhydride T=40 - 55°C; 6 h;
参考文献
Thijs, Lambertus; Keltjens, Rolf; Ettema, Gerrit J. B.
Patent: US2004/68135 A1, 2004 ;
Location in patent: Page 12 ;
反应条件
dihydrogen peroxide; trifluoroacetic anhydride in dichloromethane T=20°C; 1.66667 h;
参考文献
Chen, Bang-Chi; Zhao, Rulin; Gove, Stacey; Wang, Bei; Sundeen, Joseph E.; Salvati, Mark E.; Barrish, Joel C.
Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 10181 - 10182
反应条件
in monofluorodichloromethane 10 h; Heating / reflux;
参考文献
Thijs, Lambertus; Keltjens, Rolf; Ettema, Gerrit J. B.
Patent: US2004/68135 A1, 2004 ;
Location in patent: Page 12 ;
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=0 - 20°C; 42 h;
参考文献
Tetrahedron Letters, , vol. 54, # 18 p. 2239 - 2242
反应条件
in ethyl acetate T=20 - 55°C; Product distribution / selectivity;
参考文献
US2003/191337 A1, ;
Page/Page column 5, 12, 13 ;
反应条件
1: 88 percent / aq. H2O2; HCOOH / 2 h / 40 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 5 p. 1028 - 1040
反应条件
in dimethyl sulfoxide T=30°C; pH=9; aq. bufferAlkaline conditions; Kinetics; pH-valueTemperature;
参考文献
Asaad, Nabil; Fillery, Shaun
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 4 p. 678 - 686
反应条件
methanesulfonyl chloride; triethylamine in toluene T=10°C; Product distribution / selectivity;
参考文献
US2003/191337 A1, ;
Page/Page column 7, 12, 13 ;
反应条件
1: 97 percent / sodium hydride / dimethylformamide / 4 h / 20 °C 2: 98.6 percent / hydrogen peroxide; trifluoroacetic anhydride / CH2Cl2 / 1.67 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 68, # 26 p. 10181 - 10182
反应条件
1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 42 h / 0 - 20 °C 2: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 2.5 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 54, # 18 p. 2239 - 2242
