N-(4-氰基-3-三氟甲基苯基)甲基丙烯酰胺合成路线 （共 9 条）
参考文献
Parent, Ephraim E.; Dence, Carmen S.; Jenks, Carl; Sharp, Terry L.; Welch, Michael J.; Katzenellenbogen, John A.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 5 p. 1028 - 1040
反应条件
sodium hydride in N,N-dimethyl-formamide T=20°C; 4 h;
参考文献
Chen, Bang-Chi; Sundeen, Joseph E.; Zhao, Rulin
Patent: US2002/86902 A1, 2002 ;
反应条件
1: 2-methyl-2-propenoic acid With thionyl chloride; 2,6-di-tert-butyl-4-methyl-phenol in isobutyramide T=-4 - 0.3°C; 1.33333 h; 2: 4-amino-2-(trifluoromethyl)benzonitrile in isobutyramide T=-5.3 - 0°C; 2.08333 h; Product distribution / selectivity;
参考文献
Sumitomo Chemical Company, Limited
Patent: EP2204362 A1, 2010 ;
Location in patent: Page/Page column 4-5 ;
反应条件
1: 98.6 percent / hydrogen peroxide; trifluoroacetic anhydride / CH2Cl2 / 1.67 h / 20 °C 2: sodium hydride / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Tucker; Crook; Chesterson
Journal of Medicinal Chemistry, 1988 , vol. 31, # 5 p. 954 - 959
反应条件
1: 98.6 percent / hydrogen peroxide; trifluoroacetic anhydride / CH2Cl2 / 1.67 h / 20 °C 2: sodium hydride / tetrahydrofuran / 2 h / 20 °C 3: 255.2 g / hydrogen peroxide; trifluoroacetic anhydride / CH2Cl2 / 16 h / 20 °C View Scheme
参考文献
Tucker; Crook; Chesterson
Journal of Medicinal Chemistry, 1988 , vol. 31, # 5 p. 954 - 959
反应条件
tungsten(VI) trioxide hydrate in acetic anhydride T=40 - 55°C; 6 h;
参考文献
Thijs, Lambertus; Keltjens, Rolf; Ettema, Gerrit J. B.
Patent: US2004/68135 A1, 2004 ;
Location in patent: Page 12 ;
反应条件
dihydrogen peroxide; trifluoroacetic anhydride in dichloromethane T=20°C; 1.66667 h;
参考文献
Chen, Bang-Chi; Zhao, Rulin; Gove, Stacey; Wang, Bei; Sundeen, Joseph E.; Salvati, Mark E.; Barrish, Joel C.
Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 10181 - 10182
反应条件
in monofluorodichloromethane 10 h; Heating / reflux;
参考文献
Thijs, Lambertus; Keltjens, Rolf; Ettema, Gerrit J. B.
Patent: US2004/68135 A1, 2004 ;
Location in patent: Page 12 ;
反应条件
in ethyl acetate T=20 - 55°C; Product distribution / selectivity;
参考文献
US2003/191337 A1, ;
Page/Page column 5, 12, 13 ;
