1-(5-氯-2,3-二甲氧基苯基)乙胺合成路线 （共 2 条）
反应条件
1: With titanium(IV) isopropylate; ammonia in ethanol
T=16 - 32.4°C; 16.08 - 16.16 h;
2: With sodium tetrahydroborate in ethanol
T=1.4 - 19°C; 4.16 h;
3: With ammonia in ethanol; water
T=21 - 26°C; Product distribution / selectivity;
参考文献
PREDIX PHARMACEUTICALS HOLDINGS, INC.
Patent: WO2006/81332 A1, 2006 ;
Location in patent: Page/Page column 132-133 ;
WO 2006/081332 A1
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=110°C; 18 h; Product distribution / selectivity;
参考文献
PREDIX PHARMACEUTICALS HOLDINGS, INC.
Patent: WO2006/81332 A1, 2006 ;
Location in patent: Page/Page column 132 ;
WO 2006/081332 A1
