5-溴-2-氟-3-甲基苯甲醛合成路线 （共 3 条）
反应条件
1: 1-bromo-4-fluoro-3-methylbenzene With lithium diisopropyl amide in tetrahydrofuran
1 h; Cooling with acetone-dry ice;
2: N,N-dimethyl-formamide in tetrahydrofuran
T=20°C; 3 h;
参考文献
SCHERING CORPORATION
Patent: WO2006/81230 A2, 2006 ;
Location in patent: Page/Page column 92-93 ;
WO 2006/081230 A2
反应条件
hydrogenchloride; n-butyllithium in tetrahydrofuran; hexane; N,N-dimethyl-formamide
参考文献
Dow AgroSciences LLC; Lo, William C.; Hunter, James E.; Watson, Gerald B.; Patny, Akshay; Iyer, Pravin S.; Boruwa, Joshodeep
Patent: US2014/171308 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
1: 1-bromo-4-fluoro-3-methylbenzene With lithium diisopropyl amide in tetrahydrofuran
T=-78°C;
2: N,N-dimethyl-formamide in tetrahydrofuran
参考文献
Antonysamy, Stephen; Hirst, Gavin; Park, Frances; Sprengeler, Paul; Stappenbeck, Frank; Steensma, Ruo; Wilson, Mark; Wong, Melissa
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 1 p. 279 - 282
