N-乙基-4-三氟甲基苄胺合成路线 （共 3 条）
反应条件
1: With dimethylsulfide borane complex in tetrahydrofuran T=0 - 20°C; Heating / reflux; 2: With hydrogenchloride in water
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/294 A1, 2003 ;
Location in patent: Page 34 ;
WO 2004/000294 A1
反应条件
1: With sodium hydroxide in water; toluene 3 h; 2: With hydrogen; palladium on activated carbon in water; toluene P=1500.15 Torr;
参考文献
WO2007/8156 A1, ;
Page/Page column 35 ;
WO 2007/008156 A1
反应条件
1: 1 h / Ambient temperature 2: LiAlH4 / diethyl ether / 2 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 27, # 9 p. 1111 - 1118
