4-(3-吡啶)苯甲酸甲酯合成路线 （共 20 条）
反应条件
1: With methanol; sodium hydroxide; water T=20 - 50°C; 2: With hydrogenchloride in water pH=4;
参考文献
Beavers, Lisa Selsam; Finley, Don Richard; Finn, Terry Patrick; Gadski, Robert Alan; Hipskind, Philip Arthur; Hornback, Wiliam Joseph; Jesudason, Cynthia Darshini; Pickard, Richard Todd; Takakuwa, Takako; Vaught, Grant Mathews
Patent: US2010/48580 A1, 2010 ;
Location in patent: Page/Page column 14; 15 ;
US 20100048580 A1
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; ethanol; water
T=110°C; Suzuki Coupling; 0.666667 h; Microwave machine (MARS);
参考文献
Beavers, Lisa Selsam; Finley, Don Richard; Finn, Terry Patrick; Gadski, Robert Alan; Hipskind, Philip Arthur; Hornback, Wiliam Joseph; Jesudason, Cynthia Darshini; Pickard, Richard Todd; Takakuwa, Takako; Vaught, Grant Mathews
Patent: US2010/48580 A1, 2010 ;
Location in patent: Page/Page column 14 ;
US 20100048580 A1
反应条件
copper(l) iodide; C37H51ClFeNPPd; cesium fluoride in N,N-dimethyl-formamide
T=20°C; Stille Cross Coupling; 12 h; Inert atmosphere;
参考文献
Ma, Gaizhi; Leng, Yuting; Wu, Yusheng; Wu, Yangjie
Tetrahedron, 2013 , vol. 69, # 2 p. 902 - 909
反应条件
potassium hydroxide; tetrakis(triphenylphosphine) palladium(0); tetrabutylammomium bromide in tetrahydrofuran
2 h; Heating;
参考文献
Ishikura, Minoru; Kamada, Machiko; Terashima, Masanao
Heterocycles, 1984 , vol. 22, # 2 p. 265 - 268
反应条件
copper(l) iodide; C37H51ClFeNPPd; cesium fluoride in N,N-dimethyl-formamide
T=80°C; Stille Cross Coupling; 12 h; Inert atmosphere;
参考文献
Ma, Gaizhi; Leng, Yuting; Wu, Yusheng; Wu, Yangjie
Tetrahedron, 2013 , vol. 69, # 2 p. 902 - 909
反应条件
1: 3-iodo-pyridine With i -Pr2Zn; Li(acac) in 1-methyl-pyrrolidin-2-one
T=20°C; 12 h;
2: 4-iodo-benzoic acid methyl ester With trifuran-2-yl-phosphane; bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran
T=20°C; Negishi cross-coupling reaction; 12 h;
参考文献
Gong, Liu-Zhu; Knochel, Paul
Synlett, 2005 , # 2 art. no. G41404ST, p. 267 - 270
反应条件
1: With palladium diacetate; xantphos in N-dodecane; butan-1-ol
T=25°C; Suzuki-Miyaura Coupling; 0.0833333 h; Inert atmosphereGlovebox;
2: With cesium hydroxide monohydrate in N-dodecane; water; butan-1-ol
T=80°C; Suzuki-Miyaura Coupling; 4 h; Inert atmosphereGlovebox;
参考文献
Yang, Junfeng; Liu, Sijia; Zheng, Jian-Feng; Zhou, Jianrong
European Journal of Organic Chemistry, 2012 , # 31 p. 6248 - 6259,12
Title/Abstract Full Text Show Details
Yang, Junfeng; Liu, Sijia; Zheng, Jian-Feng; Zhou, Jianrong
European Journal of Organic Chemistry, 2012 , # 31 p. 6248 - 6259
反应条件
potassium phosphate; [1,3-bis(diphenylphosphino) propane] dichloronickel(II) in 1,4-dioxane
T=100 - 110°C; Suzuki coupling; Inert atmosphere;
参考文献
Chen, Guo-Jun; Han, Fu-She
European Journal of Organic Chemistry, 2012 , # 19 p. 3575 - 3579
反应条件
sodium hydroxide; sulfuric acid in methanol
参考文献
Burns, Christopher J.; Dankulich, William P.; McGarry, Daniel G.; Volz, Francis A.
Patent: US2002/193410 A1, 2002 ;
US 20020193410 A1
反应条件
sodium carbonate in methanol; toluene
参考文献
Merck and Co., Inc.
Patent: US5985901 A1, 1999 ;
US 5985901 A
