1-(溴甲基)-2-甲氧基-4-硝基苯合成路线 （共 5 条）
反应条件
1: AcOH / 120 °C 2: NaOH / methanol / Heating 3: MnO2 / acetone / 20 °C View Scheme
参考文献
Seto, Masaki; Aramaki, Yoshio; Imoto, Hiroshi; Aikawa, Katsuji; Oda, Tsuneo; Kanzaki, Naoyuki; Iizawa, Yuji; Baba, Masanori; Shiraishi, Mitsuru
Chemical and Pharmaceutical Bulletin, 2004 , vol. 52, # 7 p. 818 - 829
反应条件
calcium carbonate in 1,4-dioxane; water Heating / reflux;
参考文献
US2004/214798 A1, ;
Page 17 ;
反应条件
N-bromosuccinmide in tetrachloromethane
Photolysis;
参考文献
Hu, Longqin
Patent: US2004/214798 A1, 2004 ;
Location in patent: Page 17 ;
反应条件
hydrogen bromide; acetic acid
参考文献
Palmer, Brian D.; Thompson, Andrew M.; Booth, R. John; Dobrusin, Ellen M.; Kraker, Alan J.; Lee, Ho H.; Lunney, Elizabeth A.; Mitchell, Lorna H.; Ortwine, Daniel F.; Smaill, Jeff B.; Swan, Leesa M.; Denny, William A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 16 p. 4896 - 4911
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 40 °C / Inert atmosphere
2: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / tetrachloromethane / Reflux
View Scheme
参考文献
Motoshima, Kazunori; Ishikawa, Minoru; Hashimoto, Yuichi; Sugita, Kazuyuki
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 10 p. 3156 - 3172
