n-butyllithium; C31H35N2O5(1+)*Cl(1-); lithium chloride in hexane; toluene T=20°C; Michael Addition; 24 h; Inert atmosphere; chemoselective reaction;

bismuth trifluoromethanesulphonate in dichloromethane T=-70°C; 120 h;

1: acetophenone With 2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate in dichloromethane 0.25 h; cooling; 2: acetaldehyde Diethyl Acetal in dichloromethane T=20°C; 2 h; Further stages.;

PPh3 gold(I) chloro complex; water; silver trifluoromethanesulfonate; toluene-4-sulfonic acid in dichloromethane T=20°C; 20 h;

1: dihydrogen peroxide; silver nitrate / diethyl ether / 23 h / 0 - 20 °C 2: PPh3 gold(I) chloro complex; silver trifluoromethanesulfonate; toluene-4-sulfonic acid; water / dichloromethane / 20 h / 20 °C View Scheme