N,N,N',N',N'',N''-hexamethylphosphoric triamide in diethyl ether; tert-butyl alcohol T=-40°C; 48 h;

N,N,N',N',N'',N''-hexamethylphosphoric triamide; pyridine anhydride; sodium cyanide; p-toluenesulfonyl chloride 1.) CH2Cl2, 0 deg C, 2.) 50 deg C, 3 h; Multistep reaction;