acetyl chloride T=52°C; 16 h; Inert atmosphere;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11342937', constants.ctx, '0')">potassium hydroxide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1696894', constants.ctx, '0')">diethyl ether</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '1718733', constants.ctx, '0')">ethanol</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a> <br />2&nbsp;h;&nbsp;&nbsp;Heating2) pH: 3-4 (10 percent HCl);&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1.1: triethylamine; DMEG / dichloromethane / 0.5 h / 0 - 20 &deg;C / |Inert atmosphere<br />2.1: acetonitrile / 6 h / 82 &deg;C<br />2.2: 1 h / 0 - 20 &deg;C<br />3.1: toluene-4-sulfonic acid / toluene / 5 h / 111 &deg;C / |Dean-Stark<br />3.2: 18 h / 66 &deg;C<br />4.1: potassium hydroxide / water; ethanol / 3 h / 78 &deg;C<br />4.2: 20 &deg;C / pH 3<br /> <br /> &nbsp;