3-溴-N-(对甲苯磺酰基)吲哚合成路线 （共 5 条）
反应条件
bromine in tetrachloromethane
5 h; Heating;
参考文献
Harrington, Peter J.; Hegedus, Louis S.
Journal of Organic Chemistry, 1984 , vol. 49, # 14 p. 2658 - 2662
反应条件
sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate in water; benzene
1 h; Heating / reflux;
参考文献
Toray Industries, Inc.
Patent: US6642228 B1, 2003 ;
Location in patent: Page/Page column 76 ;
反应条件
1: 65 percent / potassium hydroxide / tetrabutylammonium hydrogen sulfate / H2O; toluene / 3 h
2: 80 percent / bromine / CCl4 / 2.5 h
View Scheme
参考文献
Hodson, Harold F.; Madge, David J.; Slawin, Alexandra N. Z.; Widdowson, David A.; Williams, David J.
Tetrahedron, 1994 , vol. 50, # 6 p. 1899 - 1906
反应条件
1: 65 percent / potassium hydroxide / tetrabutylammonium hydrogen sulfate / H2O; toluene / 3 h
2: 80 percent / bromine / CCl4 / 2.5 h
View Scheme
参考文献
Hodson, Harold F.; Madge, David J.; Slawin, Alexandra N. Z.; Widdowson, David A.; Williams, David J.
Tetrahedron, 1994 , vol. 50, # 6 p. 1899 - 1906
反应条件
1.1: n-butyllithium / hexane; tetrahydrofuran / 0.08 h / -110 °C / |Inert atmosphere
1.2: 0.17 h / -110 °C / |Inert atmosphere
2.1: toluene / 3 h / |Inert atmosphere; |Reflux
3.1: tetrahydrofuran; diethyl ether / 0.33 h / -78 - 20 °C / |Inert atmosphere
View Scheme
参考文献
An, Yong; Wang, Yunxia; Hu, Xiangdong
European Journal of Organic Chemistry, 2014 , vol. 2014, # 17 p. 3715 - 3718
